The Humor is very demented. A little like grim and evil, only darker and much grosser. DO NOT WATCH THIS SHOW IF YOU ARE EASILY GROSSED OUT! Stories involve Zim taking out everyone's organs, replacing them with soda cans, radiators, and very disgusting things. He then puts them inside his own body to make him look like a human. He later vomits intestines. But there are some episodes with nothing gross, just pure hilarity. Like when Zim sends a schoolbus down a wormhole, and at the end... IS A ROOM WITH A MOOSE! AHHHH!
P.S. That was from an early episode, "Parent Teacher Night"