What's the best company for ads (somehting like Adsense)? And remember, Fastclick is CRAPPISH.
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It all depends on the specifics of the site. I've found that the highest paying ads are going to be direct advertisements (we got ads from Nickelodeon twice that were excellent). Contextual is next up in line, with both Google Adsense and Yahoo Publisher Network about neck and neck (and pretty good). Either one may be better or worse for different genres. I dislike CPM ad networks like Burst, Fastclick, Tribal, and Casale because the ads are never relevant, are often annoying, and generally pay less than contextual ones.