It's coming out next year on May 22. I can't wait I love Indiana Jones.
So far the confirmed cast is this:
Harrison Ford- Indiana Jones (Duuuuuh)
Cate Blanchett- Unknown
Ray Winstone- Unkown (Probably Indy's sidekick or Marion's father)
Shia LeBouf- Rumored to be named "Mutt" Ravenwood (Probably Indy's son or a 2nd sidekick)
Karen Allen- Marion Ravenwood
It looks like Sallah (Indy's friend in ROTL & LC) will not return.
Updated: cast section.